Prof. Dr. David D. SAMPSON
David D. Sampson, Winthrop Professor, Director of the Centre for Microscopy, Characterisation & Analysis (CMCA), a core infrastructure facility of the University of Western Australia, and head of the Optical + Biomedical Engineering Laboratory (OBEL) in the School of Electrical, Electronic and Computer Engineering is visiting the Faculty of Physics and Astronomy as ASP Visiting Professor from May until July 2013. During his stay he will give a series of lectures.
Winthrop Prof. Sampson's research interests are in biomedical optical engineering, with an emphasis on photonics, imaging, and microscopy. His current main interests are advancing microscope-in-a-needle technology and optical elastography - the imaging of tissue mechanical properties. His other interests include anatomical optical coherence tomography for imaging in human airways, and holographic microscopy.
In his core facility role, he directs the Western Australian nodes of the Australian Microscopy & Microanalysis Research Facility and Australia's National Imaging Facility. He is responsible for many techniques, from secondary ion mass spectrometry, electron microscopy, and X-ray diffraction, to optical microscopy, flow cytometry and magnetic resonance imaging.
He is a Fellow of the OSA and the SPIE, and an Associate Editor of IEEE Photonics Journal, the IEEE Transactions of Biomedical Engineering and on the editorial boards of the Journal of Biomedical Optics, Photonic Sensors and Photonics & Lasers in Medicine (the journal of the German Society for Laser Medicine (DGLM) and the Swiss Laser Surgery Association (SALC)).
Website of David D. Sampson at OBELExternal link
Lecture 1: Optical Coherence Tomography I - A Tutorial
Time: May 28, 2013, 14:00
Place: Lecture Hall Institute of Photonic Technology, Albert-Einstein-Str. 9, 07745 Jena
Optical coherence tomography is placed into the context of tissue bioimaging and the basic optical properties of tissues and the issues with imaging through turbid media are introduced. We introduce the basic principles of optical coherence tomography and briefly consider its historical development.
Lecture 2: Optical Coherence Tomography II - Advanced Aspects
Time: June 4, 2013, 14:00
Place: Lecture Hall Institute of Photonic Technology, Albert-Einstein-Str. 9, 07745 Jena
We consider state-of-the-art in optical coherence tomography imaging of a range of tissues. We examine the characteristics of images and common artefacts and how to deal with them. In particular, we examine speckle and its effects commencing with a linear systems model of the OCT point spread function.
Lecture 3: Optical Coherence Tomography III - A Microscope in a Needle
Time: June 11, 2013, 14:00
Place: Lecture Hall Institute of Photonic Technology, Albert-Einstein-Str. 9, 07745 Jena
We examine the issues and technologies necessary to design effective imaging in a needle format, including basic Gaussian beam optics methods and more advanced optical design using the beam propagation method. We demonstrate needle imaging in animal and human tissues and consider a range of technical innovations in image quality, function, and navigation to enable such imaging to impact on medical applications such as breast cancer.
Lecture 4: Taking Optics Deep Into Tissues with a Microscope in a Needle
Time: June 14, 2013, 14:00
Place: Lecture Hall Institute of Photonic Technology, Albert-Einstein-Str. 9, 07745 Jena
Microscopy is usually performed in a laboratory on carefully prepared, very thin samples and achieves resolutions of better than a micrometer. Medical imaging, by contrast, is usually performed on sizeable portions of the living human body, and resolutions are rarely better than 1 millimeter.
Over the last decade, there has been great progress in applying optical microscopy techniques to the human body in a medical setting. This push has been led by optical coherence tomography (OCT), which is now in mainstream use in ophthalmology and is soon to gain acceptance in cardiology.
In this talk, 3D microscopic imaging deep inside tissue using the OCT microscope in a needle will be described. Needle delivery makes optical imaging possible in many tissues previously inaccessible to optics. This talk will include technical developments such as realization of ultra-small needles, extended imaging depth of focus, handheld micrometer-resolution tracking, and multimodality needles combined with fluorescence, and with elastography. It will also include the application of 3D OCT needle probes to animal lungs (basic physiology) and muscle (muscular dystrophy) and human breast cancer - directed towards assessing tumor margins during surgery.
Lecture 5: Optical Elastography I - Imaging Tissue Micromechanical Properties
Time: June 18, 2013, 14:00
Place: Abbe-Zentrum Beutenberg, Lecture Hall, Hans-Knöll-Str. 1, 07745 Jena
The medical imaging field of elastography is introduced, and how optics may offer advantages in elastography is considered. We go back to basics on the mechanical properties of tissue and how these might be measured using optics.
Lecture 6: Optical Elastography II - Methods
Time: June 27, 2013, 14:00
Place: Abbe-Zentrum Beutenberg, Lecture Hall, Hans-Knöll-Str. 1, 07745 Jena
A survey of current and previous optical methods of performing elastography is presented, finishing with an introduction to optical coherence elastography and phase-sensitive detection in optical coherence tomography, which forms the basis for high-dynamic-range strain imaging.
Lecture 7: Optical Elastography III - Applications
Time: June 28, 2013, 10:00
Place: Abbe-Zentrum Beutenberg, Lecture Hall, Hans-Knöll-Str. 1, 07745 Jena
The state-of-the-art of emerging optical coherence elastography methods is presented. A range of outstanding issues are presented and discussed, including the insight to be gained by finite element modeling of stress and strain, and whether or not mechanical contrast will surpass optical contrast, which would provide a major advantage for this exciting new area.